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Organic nanocrystals (NCs) with high brightness are highly desirable for biological imaging. ruohan xu However, the preparation of NCs by a facile and fast method is still challenging Herein, an aggregation-induced emission (AIE) luminogen of 4,4′-(5,6-difluorobenzo[c][1,2,5]thiadiazole-4,7-diyl)bis(N,N-bis(4-methoxy